Terminal transformation of H 2 O 2 to H 2 O circumvents H 2 O 2 accumulation, and is performed by the CAT enzyme
Creatine is a natural compound that helps with energy metabolism, especially in muscles and the brain
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Multiple studies have shown that expressions and activities of cytochrome P450 enzymes were also positively regulated by some nuclear receptors and transcription factors, including pregnane X receptor (PXR), constitutive androstane receptor (CAR), and retinoid X receptor (RXR) [124], [133], [38],]
In conclusion, metformin could ameliorate inflammation and oxidative stress in renal tubular cells, regulate apoptosis and autophagy, and attenuate tubulointerstitial damage through various mechanisms
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