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These patients face elevated b12 deficiency risk regardless of medication use

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For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance

Investigators have studied the compound in combination with other research molecules, in biomaterial-integrated delivery formats, and in cell-type-specific contexts that broaden the mechanism understanding documented in foundational papers

The regulatory status varies by country and jurisdiction