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Interferon with or without ribavirin is the only drug with proven efficacy in treating chronic HCV infections [20]

Thermodynamic analyses using ESI-MS revealed that cellular copper transport follows a gradient of increasing binding affinity, with Cu + binding to GSH ( K d~10 13 M) at lower affinity than to dedicated copper chaperones such as antioxidant 1 copper chaperone (ATOX1), copper chaperone for superoxide dismutase (CCS), or cytochrome oxidase copper chaperone COX17 (COX17) 197

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In adipose tissue, we observed that CI respiration was rhythmic across gWAT and iWAT, and was reduced by Bmal1 loss, whereas respiration through CIICIV was not affected by loss of the clock

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