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However, given the safety or effectiveness concerns of anti-obesity drugs, many of the currently used drugs have limited clinical use

The highest approved dose of oral semaglutide (14 mg/day) is currently indicated only for treating T2DM as an adjunct to diet and exercise

The Satiety and Clinical Adiposity Liraglutide Evidence (SCALE) Obesity and Prediabetes randomized, double-blind, placebo-controlled trial of 3.0 mg of once daily liraglutide achieved a mean 8.4 kg weight loss in patients with obesity without T2DM [7]

FAERS, FDA Adverse Event Reporting System