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Receptor sensitivity to dopamine could be diminished, which would explain the lack of response to increased endogenous dopamine stimulation

Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation

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It was shown that long-term treatment (72 h) of hippocampal slices with BDNF (250 ng/mL) increases synapse number and spine density at the level of apical dendrites of pyramidal neurons in the hippocampus [35], suggesting that BDNF acts selectively on different types of spines, depending on the level of basal, spontaneous synaptic transmission

By contrast, rats bearing GH-secreting tumors displayed significant glomerular hypertrophy and interstitial edema but no tubular hypertrophy, resulting in a 1.6-fold increase in kidney weight in relation to body weight compared to controls [95]

IM injections allow for slow absorption into the blood, providing a longer-lasting effect