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Reduction in enzyme activity associated with collagen breakdown

Sources Food sources Cruciferous vegetables Cruciferous vegetables, such as bok choi, broccoli, Brussels sprouts, cabbage, cauliflower, horseradish, kale, kohlrabi, mustard, radish, rutabaga, turnip, and watercress, are rich sources of glucosinolate precursors of isothiocyanates (63)

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PMID: 3029331

Gradual escalation over 16 to 20 weeks is the standard clinical protocol precisely because it minimizes GI symptoms while still reaching a therapeutic dose