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Starting at a high dose triggers severe gastrointestinal side effects in most people

347 Activated TGF- binds to its transmembrane receptor (TR), subsequently inducing the phosphorylation of suppressor of mothers against decapentaplegic (SMAD) and its translocation into the nucleus, which suppresses hepatocyte proliferation by inhibiting the expression of downstream DNA synthesis-related genes

This injection is administered by a healthcare professional, either intramuscularly (into a muscle) or intravenously (into a vein)

Scand J Gastroenterol 29(sup204):115

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For example, the enzymatic activity of superoxide dismutase and glutathione peroxidase in semen is essential to limit ROS levels and prevent oxidative stress in sperm (79, 80)