Figure 3 3.5 Association between GLP-1RA exposure and cocaine use disorder Exposure to GLP-1 RA was significantly associated with a reduced odds of CUD (OR = 0.25, 95%CI: 0.160.40, p = 0.0001)
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People with certain medical conditions, such as severe kidney disease, heart failure, or specific electrolyte imbalances, may need to avoid these treatments
Very rare in the trials and not consistently linked to retatrutide specifically, but a known concern across the GLP-1 family
Animal experiments and studies of human subjects have shown that IOP-independent factors include oxidative stress, glutamate excitotoxicity, and impaired retinal blood flow 6,7,8
This is consistent with FY2026 CMS guidance for Z code screening categories