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Indeed, melatonin is highly permeable to cell membranes and easily crosses the bloodbrain barrier 51 , ensuring a good therapeutic profile for brain diseases, and is also able to accumulate into mitochondria, probably via GLUT/SLC2A and PEPT1/2 carriers 52,53

Glutathione-S-transferase catalyzes the conjugation of glutathione and a wide variety of electrophilic compounds (both endogenous and exogenous): this is the first step in the mercapturic acid pathway, a crucial component of system detoxification

Endoplasmic Reticulum stress leads to protein misfolding and activation of the unfolded protein response (UPR), which promotes ROS generation, influencing cell survival and drug resistance [73]

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