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Abrupt discontinuation can cause appetite rebound, rapid weight regain, blood sugar fluctuations, and other withdrawal effects

This was because the drug has a half-life of 2-4 hours (Holst 2024)

7 While that makes hair shedding far less common than nausea or gastrointestinal symptoms, it is frequently discussed within online weight-loss communities and is one of the more common reasons patients in Newport Beach and Orange County are now seeking evaluation for hair restoration alongside their weight-loss treatment

8-10 The ability of GLP-1 and GLP-1/GIP RAs to lower glucose as well as reduce weight led to their initial approvals for use in patients with type 2 diabetes and obesity

LillyDirect, the company direct-to-consumer platform, offers Zepbound at $299 per month for the 2.5 mg starting dose, with higher doses available at $449 to $499 per month

The short answer Berberine is a natural compound with genuine, if modest, effects on blood sugar and, to a smaller degree, body weight in clinical trials