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Among them, the most typical is the chemokine Leukotriene B4 (LTB4), the increased expression of which causes recruitment of neutrophils, ATMs, T cells, and B cells, which increase expression of pro-inflammatory cytokines, eventually leading to the development of eWAT inflammation and obesity (132) ( Figure 3 )

Corcoran RB, Atreya CE, Falchook GS, Infante JR, Hamid O, Messersmith WA, Daud A, Kwak EL, Ryan D, Kurzrock R, Sun P, Cunningham EA, Orford KW, Motwani M, Bai Y, Patel K, Venook AP, Kopetz S

A primary concern in any growth-promoting therapy is the regulation of insulin-like growth factor 1 (IGF-1)

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