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Semaglutide, Tirzepatide, Retatrutide, and Beyond While all GLP-1RAs share core mechanisms, important differences exist between these medications: Semaglutide (Ozempic, Wegovy) features weekly dosing and has demonstrated substantial weight loss effects (approximately 15% body weight reduction)

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95% CI, 0.77-0.84), though the SGLT2 inhibitor group had higher rates of diabetic ketoacidosis, genital infections and lower limb amputations

Furthermore, reduced food intake due to appetite suppression may result in inadequate nutrition, including insufficient protein, vitamins, and minerals essential for muscle health