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It modulates nitric oxide pathways to normalize lower esophageal sphincter function, reduces oxidative stress markers like malondialdehyde, and decreases inflammatory cytokine expression (TNF-, IL-6)

Furthermore, dedicated cardiovascular outcome trials (LEADER, SUSTAIN-6, REWIND)[26, 28, 29] have demonstrated consistent reduction in major adverse cardiovascular events with long-acting GLP-1 RAs, particularly in people with established ASCVD

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Meat intake and risk of diverticulitis among men [prospective cohort study, weak evidence] Out of the population of 46,461 men followed, only 764 cases of diverticulitis occurred over 18 years, meaning only 1.6% of the population developed the condition over this long time span