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Changes in the microbiota are correlated with the development of obesity, insulin resistance, and diabetes, presumably because of the ability of the microbes to extract energy from the diet (11), altered fatty acid metabolism within the adipose tissue and liver (13), changes in the levels of gut hormones like peptide YY (14), activation of lipopolysaccharide toll-like receptor-2 (15), and changes in the intestinal barrier integrity (16)

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Initially approved for type 2 diabetes in the UK, its now widely prescribed for weight loss due to its significant effects on appetite reduction and supporting weight loss

Ozempic , which targets the GLP-1 receptor, can also support significant weight loss by reducing appetite and increasing satiety

The activation of the Nrf2 pathway triggers a massive endogenous production of Phase II detoxification enzymes, including Heme Oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)

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