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The anti-inflammatory effect of curcumin is most likely associated with its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS) (164)

Researchers have found an increased expression of renal markers of senescence, such as p16, p19, and p53, in a high-fat-diet-induced mouse model

This reciprocal relationship is critical, as disruptions in the gut microbiota are associated with liver diseases (51)

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