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In separate large obesity trials, semaglutide 2.4mg led to 14.9% mean weight loss at 68 weeks in STEP-1 (n=1,961), while tirzepatide 15mg led to 20.9% mean weight loss at 72 weeks in SURMOUNT-1 (n=2,539)

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Research indicates that GLP-1RAs can ameliorate hepatic steatosis by regulating lipid synthesis pathways and enhancing fatty acid oxidation