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It signals via a completely different biochemical pathway than GHRH

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Highlights Diabetic kidney disease (DKD) is one of the most common and debilitating complications of diabetes mellitus, affecting approximately 40% of people with diabetes mellitus and representing the leading global cause of end-stage kidney disease (ESKD) [1]

In addition, peripheral inflammationlinked to comorbid conditions like diabetes and HIVmay exacerbate central neuroinflammatory responses (Isik et al., 2023

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