In the same clinical trial, patients lost 4-5% of their initial body weight by 8 weeks or 2 months
And men, on average, carry more of it at any given BMI than women
Therefore, the anti-ferroptosis function of DHODH is dependent on CoQ
As of January 2026, the FDA has not approved tirzepatide in any oral form, including a pill, tablet, capsule, dissolvable oral product, sublingual product, or oral drops
Conversely, at current prices, GLP-1 RAs are unlikely to meet the arbitrary AU$28,000 per QALY willingness-to-pay threshold in either the total or secondary prevention population when considering only their benefits on CVD
Practical implication: the proposed rule closes one major access pathway (503B industrial-scale compounding) while leaving the other (503A patient-specific compounding) operational under separate regulatory standards