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It suppresses NF-kB signaling through a receptor-independent intracellular mechanism, reducing inflammatory cytokine production without causing immunosuppression

PMID: 29986520 Tertiary SOD / Anti-Inflammatory Copper-Dependent Enzyme Activation As a bioavailable copper delivery system, GHK-Cu supports the activity of copper-dependent enzymes including superoxide dismutase (SOD), cytochrome c oxidase, and lysyl oxidase

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This isn't just increased flow through existing vessels

Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1