This may lead to impairment of cellular signaling mechanisms and accumulation of misfolded proteins causing proteotoxicity associated with cardiac dysfunction (136143)
With toxicity, manganese-induced damage is found in the substantia nigra, globus pallidus, and caudate nucleus with depletion of dopamine and serotonin levels and has been linked to psychiatric changes followed by impaired motor activity with muscle rigidity and tremors
Additionally, glutathione supports the recycling of other antioxidants like vitamins C and E
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Research involving this compound typically focuses on copper peptide signaling behavior, skin matrix pathway activity, collagen pathway research, extracellular matrix response, peptide-metal complex activity, cellular signaling, structure-function relationships, and measurable cellular response in experimental systems
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