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Kynurenine is predominantly metabolized to the N -methyl-d-aspartate (NMDA) receptor agonist quinolinic acid (QUIN) in the inflammatory state, contributing to the accumulation of glutamate in the extracellular space, leading to changes in network connectivity associated with depression, fatigue and cognitive impairment

Klein, R., et al

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doi: 10.1080/01140671.2022.2135543 47 KaragiannisE.MichailidisM.TanouG.SamiotakiM.KaramanoliK.AvramidouE.et al