Older adults may experience side effects slightly later but potentially more persistently, while younger patients often adapt faster
Both are increased gradually at four-week intervals to reduce side effects and find the right dosage for everyone

collapse Signs of sepsis: high fever or very low temperature, rapid breathing, confusion, or feeling extremely unwell following an injection Severe hypoglycaemia with loss of consciousness or inability to swallow Severe chest pain or significant difficulty breathing Contact your GP or a healthcare professional promptly if you experience: Injection site reactions such as persistent redness, swelling, warmth, or pain, which may indicate infection or an inflammatory response Systemic symptoms including fever, chills, or malaise following administration Gastrointestinal symptoms such as severe or persistent nausea, vomiting, or abdominal pain these are known effects associated with GLP-1 receptor agonism and may require clinical assessment [15] [6] Symptoms of hypoglycaemia shakiness, sweating, confusion, or palpitations particularly if retatrutide is being used alongside other glucose-lowering agents Cardiovascular symptoms such as a rapid or irregular heartbeat Report suspected side effects via the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk

Key adverse effects include sexual dysfunction and, rarely, mood changes
10.1016/j.freeradbiomed.2006.01.035 Free Radic Biol Med
Action Item : Update your patient education materials to include oral option as first-line conversation point for appropriate patients