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Abstract PURPOSE Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem neurologic disease characterized by profound fatigue and decreased functional capacity, postexertional malaise, and unrefreshing sleep, along with cognitive impairment and/or orthostatic intolerance

The clinical evidence is weaker than the skin evidence but reasonable

Most patients safely resume GLP-1 therapy within 24 to 72 hours after minor procedures

This arylamine group and another nitrogen-containing ring found in antimicrobial sulfonamides are the primary targets, or determinants, for allergic sensitization