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A 2025 review of research papers and patents by Jzwiak and colleagues examined the larger BPC-157 literature, reviewing preclinical data across cellular signaling, tissue biology, pharmacology, and other areas of scientific investigation

Blair RM, Fang H, Branham WS, et al

Is the systemic effect of BPC-157 proven in human trials

FIGURE 2 3.2 Inflammatory pathway activation via mtROS and mtDNA leakage 3.2.1 mtROS and the NLRP3 inflammasome mtROS is a potent activator of the NLRP3 inflammasome, a multiprotein platform composed of NLRP3, ASC, and caspase-1 (Wang et al., 2024)

Variations between means were assessed by least of significant differences (LSD) at 0.05

Plasma Oxidized Glutathione: Showed no significant changes in either group