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A large multicenter study (n = 1,513) demonstrated that integrating proteomic (alpha-2-macroglobulin, cathepsin D, CD324) and metabolomic (galactose, glycerolipid pathways, glycerol-3-galactoside) data substantially improved classification precision versus single-omics approaches (Liu et al., 2021)

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To extend this approach beyond protein bound to beads, we next analysed human recombinant Cofilin 1 treated with MitoPerSulf, which forms persulfides (PrSS ) on Cys39 and Cys139, as was demonstrated previously by LC-MS peptide profiling 47

In this experiment, arterial blood gas results indicated different degrees of hypoxia in groups B, C and D animals housed in a hypobaric hypoxic animal chamber: decreased PO 2 , increased PCO 2 , increased Hb or HCT, and elevated K + and Cl levels

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