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GHK levels reflect regenerative capacity, and GHK plays an important role in tissue remodeling processes (Pickart, 2008)wound healing and skin remodelinginduced by the stimulation of collagen and glycosaminoglycan synthesis and breakdown (Wegrowski et al., 1992)

and Faecalibacterium prausnitzii are the two most abundant butyrate producers, typically constituting 510% of the detectable fecal bacteria in healthy adults [13]

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However, in addition to this, these hormones can also influence bone turnover by directly, or indirectly, modulating the activity of osteoblast and osteoclast cells