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Menadione treatment depleted cellular GSH and reduced the GSH/glutathione disulfide ratio, but glutathione amino acid precursor supplementation effectively restored GSH levels and improved the redox balance

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Above the high-risk line (300 ug/mL at 4 hours) indicates a high risk of liver failure (massive ingestion), which may warrant even more aggressive therapy (discussed below)

Ammonia is the product of the metabolism of nitrogenated substances, derived mostly from proteins, and its primary elimination pathway is via the urea cycle in hepatocytes

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