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[1] [2] Studies typically report an average increase of about 24 beats per minute , though some patients may experience larger increases

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and in humans, HPX recycling has been implicated from plasma heme clearance studies ( In cultured cells, hemeHPX binding and heme delivery initiate a cytoprotective program of events (Montecinos et al., 2019), including the induction of the heme degrading enzyme heme oxygenase (HMOX1)