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Among the diverse ncRNAs, miRNAs and lncRNAs have been the most extensively characterized, collectively functioning as regulators of inflammatory and injury responses 120,121

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Studies show improved pain and function in over 80% of appropriately selected patients within 36 months

Second, Edaravone is used to treat stroke and amyotrophic lateral sclerosis, with moderate clinical effects [432,433,434,435]

SIRT1 inhibitor (NAM) leads to a decrease in phosphorylation of AMPK in human hepatocytes, indicating that SIRT1 stimulates AMPK (Fig