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Sm14-specific antibody titers were detected up to 12 months after initial immunization (113)

Additionally, the coincidence between glutamate dysregulation and microglial activation was assessed by evaluating the activated microglial marker Iba-1

The 2.5-milligram dose is intended for treatment initiation rather than long-term maintenance

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Plates were incubated at 37C for 2 h and then fluorescence was measured with excitation at 360 nm and emission at 460 nm using a ClarioStar Monochromator Microplate Reader (BMG LABTECH, Ortenberg, Germany)