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Whilst these injections can be highly effective for weight reduction, some patients report experiencing tiredness or fatigue during treatment
A companion phase III trial reported a -10.9% reduction in visceral adipose tissue (a 21 cm decrease) in the tesamorelin group compared with -0.6% in the placebo group over the six-month efficacy phase, alongside significant improvements in trunk fat, waist circumference, and waist-hip ratio, with the authors concluding that tesamorelin reduces visceral fat by approximately 18% and improves body-image distress in HIV-infected patients with central fat accumulation, without significant side effects or disruption of glucose control
A sharp drop in appetite may unintentionally reduce protein, fiber, and overall nutrient intake
As awareness about newer treatment options rises among both healthcare professionals and patients, adoption of these therapies continues to expand