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To alleviate the gastrointestinal reaction of patients, at the beginning of the application of these drugs, clinical workers should know that the dosage should be gradually increased from a small dosage to enhance patients tolerance

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5,6 In addition, receptor activator of nuclear factor kappa beta ligand (RANKL), that plays a crucial role in osteoclast activity and bone resorption, 21 also directly influences pancreatic beta-cell function and overall metabolism, with its activity being compromised in obesity and T2D

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