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Following the Phase Ib readout, Zealand expects to initiate a mid-stage study for petrelintide imminently, with data expected by the end of 2025 or early 2026, as per the Leerink note

An innovative fluid dynamic system to model inflammation in human skin explants

tirzepatide adds GIP (dual agonist) and retatrutide adds glucagon (triple agonist), with generally larger weight effects in trials but different tolerability profiles

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Since most glucose-dependent insulinotropic polypeptide (GIP) receptor: glucagon-like peptide- 1 receptor (GLP- 1) receptor: glucagon receptor triagonists compete in efficacy with bariatric surgery, the success of these agents in preclinical models and clinical trials suggests a bright future for multi-agonists in the treatment of metabolic diseases

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