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The GLP-1 Clinical Trial Landscape in 2024 Glucagon-Like Peptide-1 (GLP-1), Semaglutide, and other GLP-1 targeting drugs are involved in many clinical trials as of July 2024

doi: 10.1210/jc.2009-1503

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These benefits appeared independent of changes in glycated haemoglobin (HbA1c) or BMI, suggesting a direct neuroprotective effect of GLP-1RAs [89]

The difference becomes relevant when you also bring mazdutide vs retatrutide into the conversation, since Retatrutide covers all three pathways including GIP, glucagon, and GLP-1