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GLP-1R knockout mice (GLP-1R KO, Shanghai Model Organisms, based on C57BL/6N) were generated using CRISPR/Cas9 technology, which causes Glp1r gene protein reading frame shift and loss of function by using non-homologous recombination repair to introduce mutations

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Interestingly, some other studies have found that lean body mass might decrease overall, but the proportion of lean mass to total body mass increased, which might be considered a positive change in body composition