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Both conditions can cause abdominal distension, cramping, severe constipation, nausea, vomiting, dehydration, and inability to pass gas or stool

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6 GLP-1 role in sepsis pathophysiology In addition to its significant role in regulating glycemia, GLP-1 exhibits numerous pleiotropic properties that may be relevant in the pathophysiology of sepsis

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Supporting Information Supporting Table 1 depicts the quality of evidence using the GRADE assessment for the primary outcome of weight loss with three doses of tirzepatide vs GLP-1 agonists or placebo