[62] PHA-665752 (Pfizer) specifically inhibits MET kinase activity, and it has been demonstrated to represses both HGF-dependent and constitutive MET phosphorylation
Hepatology 78 , 18281842 (2023)
doi: 10.2174/092986707779941159
Tirzepatide (Zepbound and Mounjaro): weekly vials you load into a syringe yourself or preloaded injection pens Semaglutide (Wegovy and Ozempic): weekly, preloaded injection pen in various doses Liraglutide (Saxenda and Victoza): daily injectable pens Other GLP-1s and weight-loss meds: Trulicity , a less common GLP-1 (dulaglutide), comes in the form of a pen for once-weekly injections Bydureon BCise (once-weekly preloaded injection) Rybelsus (oral method) Contrave and Xenical (weight-loss drugs that are not GLP-1s and typically come at a much cheaper price tag) Other medications: antibiotics, antidepressants, asthma medication, and much, much more Note: Ozempic, Mounjaro, Victoza, Trulicity, Bydureon, and Rybelsus are FDA approved for type 2 diabetes only and must be prescribed off-label for use as a weight-loss treatment
Due to inadequate insurance coverage, limited availability, and high costs, many people are turning to compounded GLP-1 RAs, which are often cheaper and easier to access but lack standardized efficacy, safety, and dosage information, and their safety profile is largely unknown
The strongest single piece of human evidence is Watson et al
