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A network meta-analysis comparing the effects of glucose-lowering therapy on body weight and blood pressure indicates that the greatest efficacy for reducing body weight is seen with subcutaneous semaglutide followed by the other GLP-1 RA and SGLT2i, and the greatest reduction in blood pressure is seen with the SGLT2i and GLP-1 RA classes [224]
A phase 2 trial published in the New England Journal of Medicine showed average weight loss of over 24% at 48 weeks, and the first phase 3 results in December 2025 suggested that average weight loss could be around 28 to 29%
A study has also witnessed this
Understanding these timelines, alongside factors that influence response rates, helps set realistic expectations and supports successful outcomes with GLP-1 therapy
Current trials include participants with obesity, both with and without related conditions such as osteoarthritis or sleep apnoea