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Increases levels of Interleukin-2, Interleukin-12, and Interferon-gamma, cytokines, which are known to be crucial for the control of intracellular pathogens

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This is why the recommendation for T/T individuals is specifically active folate rather than folic acid folic acid accumulates as unmetabolized folic acid in the circulation of T/T individuals, potentially with pro-inflammatory consequences, rather than supplementing the genuinely deficient 5-MTHF pool

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