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p53 is activated upon genotoxic and oxidative stress, which activates AMP-responsive protein kinase (AMPK) through the tuberous sclerosis (TSC) 1/TSC2 complex and inhibits mTOR activity to promote autophagy

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Bluestone, M.D., professor of otolaryngology at the University of Pittsburgh School of Medicine (UPMC)

Subramanian S, Liu C, Aviv A, Ho JE, Courchesne P, Muntendam P, Larson MG, Cheng S, Wang TJ, Mehta NN, Levy D