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A 2014 systematic review and meta-analysis of 14 RCTs reported that certain probiotics produced small improvements in gut transit time and stool frequency, with effects varying by strain.[5] Since semaglutide also causes constipation (and constipation can contribute to bloating), this category has indirect relevance, though the trials were not in semaglutide users

Skin lightening treatment is designed to decrease excessive melanin in the skin

This is also an FDA approved treatment for Weight Loss, and Type 2 Diabetes

Reasonable confounding factors did not significantly affect the validity of the results, leading to a high quality of evidence rating for these outcomes (Table 4)

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Furthermore, given the limited sample size and the heterogeneity of the antipsychotic drugs administered, results should be interpreted with caution