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Although the scientific conclusions of the paper appear sound and its key findings have been extended by other investigators in independent publications, in an abundance of caution all authors who contributed experiments at the Broad Institute of MIT and Harvard support the Nature editors recommendation to retract the paper, says David Cameron, Broad Institutes director of communications

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The weaker binding and lower occupancy levels (~20%) of BV in Ab DPcob suggest that evolutionary pressures may have reduced the requirement for BV and resulted in a different role for the globin-like domain in these more complex fusion proteins

This selective activity may support chondrocyte function and extracellular matrix synthesis while avoiding the complications associated with systemic growth hormone elevation