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J744A.1 is a differentiated mouse macrophage cell line and cultured cells secrete inflammatory cytokines in the nutrition medium

In a retrospective analysis of ninety-day toxicity study data from eighty-three mouse studies and eighty-seven rat studies that were also tested for carcinogenicity, the combined presence of hepatocellular necrosis, hepatocellular hypertrophy, hepatocellular cytomegaly, bile duct hyperplasia, and hepatocellular degeneration, along with increased liver weight, was significantly predictive of hepatocarcinogenicity in the two-year study (Allen et al

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The proposed mechanism involves GIPR-mediated upregulation of uncoupling protein-1 (UCP-1) in brown adipose tissue [25]

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