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Recent studies demonstrated isorhamnetin possesses significant anti-inflammatory effects on macrophages, including regulating macrophage inflammatory responses in conditions such as cord injury, atherosclerosis, and osteoarthritis, leading to M1 macrophage inhibition and M2 macrophage upregulation (Jian et al., 2024) clarified that isorhamnetin markedly upregulated SLPI to inhibit the Mincle/Syk/NF-B signaling pathway, which diminished M1 macrophage differentiation while facilitating M2 macrophage differentiation to attenuate AKI-triggered renal inflammatory reactions

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Footnotes References 1 GhezziPJaquetVMarcucciFSchmidtHH

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the connections of the mouse olfactory bulb: a study using orthograde and retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase