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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a recently discovered mitochondrial-derived peptide that plays a crucial role in cellular energy metabolism and metabolic homeostasis

The natural breathing reflex is regulated by the autonomic nervous system and responds automatically to changes in blood carbon dioxide levels

*Correspondence: Yamin Li [email protected] This article was submitted to Molecular Psychiatry, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Therefore, these guidelines represent a conditional GRADE recommendation for clinical practice

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Figure 6 ) with a beta pleated sheet domain at the N-terminus and alpha helix domain at the C-terminus separated by a serine/threonine-rich linker region