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Adding glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism alongside GLP-1R creates a genuinely different metabolic research profile not just an incremental improvement

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Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect

Notably, melatonin also diminished the activity of PKA in a rat model [121], a known trigger for tau hyperphosphorylation by GSK3 [122, 123]

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