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Frontiers in Physiology , 12, 688

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Support for this hypothesis comes from the finding that, in ovariectomized rats, estradiol replacement enhances peripheral GLP-1 induced suppression on food intake (199, 200)

Ozempic works through several complementary mechanisms: it stimulates insulin secretion from the pancreas when blood glucose levels are elevated, suppresses the release of glucagon (a hormone that raises blood sugar), slows gastric emptying to reduce post-meal glucose spikes, and acts on appetite centres in the brain to promote satiety

The results suggested that neither the change in A1c nor the change in body weight during the trial influenced the cardiovascular benefits of oral semaglutide