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Research Triangle Park, NC: Grifols Therapeutics Inc

The GSH/GPX4 node is the crucial regulator of ferroptosis The GSH system, as a lipid peroxide scavenger, has attracted much attention as a potential therapeutic target for ferroptosis

Moreover, elevated GSH levels can protect tumor cells by reducing the cytotoxic effects of several chemotherapy drugs, including cisplatin, doxorubicin, melphalan, and paclitaxel, ultimately leading to drug resistance [17]

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doi: 10.5812/nms.10661 64 MathewsDMPeartJMSimRGJohnsonNPOSullivanSDerraikJGBet al