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Limiting blood from ethnic-matched donors has reduced but did not eliminate alloimmunization ( RHD or RHCE genotype due to variant RH alleles in a large proportion of the individuals ( RH genotyping in addition to serologic typing may be required to identify the most compatible RBCs and recent studies have shown that a prospective rather than reactive (after appearance of allo-antibodies) genotyping approach may be feasible ( 0 -thalassemia was demonstrated in the Transfusion Alternatives Preoperatively in Sickle Cell disease (TAPS) study ( Insight on the pathophysiology of SCD (Figure 2) has allowed different targets for interventions in patients with SCD summarized under four categories of its pathobiology (1)

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