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A licensed prescriber (MD, DO, NP, or PA depending on state scope) must attest that the patient has no contraindications to GLP-1 therapy, including personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2

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A pilot study with metformin supplementation in 21 children and adolescents with PWS showed an improvement of the food-related distress and anxiety, evaluated by hyperphagia questionnaire, but no effects on body weight [19]